Daytime Hypersomnolence in COVID-19: A Case Report and Literature Review
Abstract
Coronavirus infectious disease 2019 (COVID-19) is confirmed to develop neurocognitive complications. In the present paper, we describe two patients with laboratory-confirmed COVID-19 and excessive daytime sleepiness. In the present study, we reported two laboratory-confirmed cases of COVID-19 with excessive daytime sleepiness. Patients had drowsiness and mild confusion on presentation. In both cases, CNS infections, including meningitis and encephalitis, were ruled out. Both patients’ symptoms remarkably improved following the therapeutic course indicating the direct effect of SARS-CoV2 in sleep modulating centers on the brain. COVID-19 should be considered in patients with excessive daytime sleepiness and drowsiness in the current outbreak.
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2. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. jamanetwork.com [Internet]. 2020 Jun 1 [cited 2020 Sep 9];77(6):683. Available from: https://jamanetwork.com/
3. Weiss S, research JL-A in virus, 2011 undefined. Coronavirus pathogenesis. Elsevier [Internet]. [cited 2020 Sep 9]; Available from: https://www.sciencedirect.com/science/article/pii/B9780123858856000092
4. Rothan H, autoimmunity SB-J of, 2020 undefined. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Elsevier [Internet]. [cited 2020 Sep 9]; Available from: https://www.sciencedirect.com/science/article/pii/S0896841120300469
5. Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Vol. 12, Frontiers in Cellular Neuroscience. Frontiers Media S.A.; 2018.
6. Fotuhi M, Mian A, Meysami S, Raji CA. Neurobiology of COVID-19. Vol. 76, Journal of Alzheimer’s disease : JAD. NLM (Medline); 2020. p. 3–19.
7. Postiglione E, Antelmi E, Pizza F, Lecendreux M, Dauvilliers Y, Plazzi G. The clinical spectrum of childhood narcolepsy [Internet]. Vol. 38, Sleep Medicine Reviews. W.B. Saunders Ltd; 2018 [cited 2020 Sep 12]. p. 70–85. Available from: https://pubmed.ncbi.nlm.nih.gov/28666745/
8. Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004 Jun;203(2):631–7.
9. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol [Internet]. 2020 Jun 1 [cited 2020 Sep 12];77(6):683–90. Available from: https://jamanetwork.com/
10. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron [Internet]. 2000 [cited 2020 Sep 12];27(3):469–74. Available from: https://pubmed.ncbi.nlm.nih.gov/11055430/
11. Jacob L, Dauvilliers Y. La narcolepsie avec cataplexie: une maladie auto-immune? [Internet]. Vol. 30, Medecine/Sciences. Editions EDK; 2014 [cited 2020 Sep 12]. p. 1136–43. Available from: https://pubmed.ncbi.nlm.nih.gov/25537044/
12. Rocca FL, Pizza F, Ricci E, Plazzi G. Narcolepsy during childhood: An update [Internet]. Vol. 46, Neuropediatrics. Hippokrates Verlag GmbH; 2015 [cited 2020 Sep 12]. p. 181–98. Available from: https://pubmed.ncbi.nlm.nih.gov/25961600/
| Files | ||
| Issue | Vol 59, No 12 (2021) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v59i12.8068 | |
| Keywords | ||
| SARS-CoV-2 COVID-19 Sleep Excessive Somnolence Disorders. | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Shabani M, Rahimi B, Mehrabi Nejad MM, Erfanian R, Najafi A. Daytime Hypersomnolence in COVID-19: A Case Report and Literature Review. Acta Med Iran. 2021;59(12):740-742.
