Comparison of Pregabalin and Placebo Effects in Treating Eye Pain Following Cataract Surgery by Phacoemulsification Method
-
Fardin Yousefshahi
,
Hossein Majedi Ardakani
,
Mehdi Sanatkar
,
Reza Atef yekta
,
Alireza Takzare
,
Ebrahim Espahbodi
Abstract
Cataract surgery sometimes is associated with adverse effects, such as dryness, burning, and patient discomfort. This study evaluates the treatment of dry eye syndrome and pain caused by corneal damage following cataract surgery with pregabalin compared to placebo. In our double-blind clinical trial, a total of 60 cases were divided into two groups. The pain score was assessed by the Numeric Rating Scale (NRS), and the impact of pain and dryness on the patient's performance was evaluated by the Brief Pain Inventory (BPI). The patient's pain score was evaluated postoperatively and followed for six weeks after the procedure. After the sixth week of the study, NRS, BPI, and photophobia in the pregabalin group were significantly different from the placebo group. Pregabalin can significantly reduce chronic and resistant eye pain after cataract surgery.
1. Belmonte C, Aracil A, Acosta MC, Luna C, Gallar J. Nerves and sensations from the eye surface. Ocul Surf 2004;2:248-53.
2. Belmonte C, Acosta MC, Merayo-Lloves J, Gallar J. What causes eye pain? Curr Ophthalmol Rep 2015;3:111-21.
3. Goulden CB. The control of ocular pain. Proc R Soc Med 1943; 36: 408-10.
4. Levitt AE, Galor A, Weiss JS, Felix ER, Martin ER, Patin DJ, et al. Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent postoperative pain disorders. Mol Pain 2015;11:21.
5. Quinto GG, Camacho W, Behrens A. Postrefractive surgery dry eye. Curr Opin Ophthalmol 2008;19:335-41.
6. Yoon SY, Bae SH, Shin YJ, Park SG, Hwang S-H, Hyon JY, et al. Low serum 25-hydroxyvitamin D levels are associated with dry eye syndrome. PLoS One. 2016;11:e0147847.
7. Roberts C, MacLeod J, Elkington A. Ocular pain: a casualty study. The spectrum and prevalence of pain in acute eye disease. Eye (Lond) 1997;11:342-4.
8. Espahbodi M, Noorossana R. Applied Statistics with Minitab Software for Analytical Chemistry.1st ed. Tehran: IUST, 2018.
9. Shah-Desai S, Tyers A, Manners R. Painful blind eye: efficacy of enucleation and evisceration in resolving ocular pain. Br J Ophthalmol 2000;84:437-8.
10. Matsuura M, Ando F, Sahashi K, Torii Y, Hirose H. The effect of stellate ganglion block on prolonged postoperative ocular pain. Nippon Ganka Gakkai Zasshi 2003;107:607-12.
11. Hsu JK, Johnston WT, Read RW, McDonnell PJ, Pangalinan R, Rao N, et al. Histopathology of corneal melting associated with diclofenac use after refractive surgery. J Cataract Refract Surg 2003;29:250-6.
12. Cho H, Wolf KJ, Wolf EJ. Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution. Clin Ophthalmol 2009;3:199-210.
13. Smith S, Lorenz D, Peace J, McLeod K, Crockett R, Vogel R. Difluprednate ophthalmic emulsion 0.05%(Durezol®) administered two times daily for managing ocular inflammation and pain following cataract surgery. Clin
Ophthalmol 2010;4:983-91.
14. Joshaghani M, Nazari H, Falavarjani KG, Shokrollahi S, Ghaempanah MJ, Aghdam KA, et al. Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study. Saudi J Ophthalmol 2013;27:83-5.
15. Roberts C, Elie E. Dry eye symptoms following cataract surgery. Insight 2007;32:14-21.
16. Galor A, Levitt RC, Felix E, Martin ER, Sarantopoulos C. Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond) 2015;29:301-12.
17. Rajpal RK, Ross B, Rajpal SD, Hoang K. Bromfenac ophthalmic solution for the treatment of postoperative ocular pain and inflammation: safety, efficacy, and patient adherence. Patient Prefer Adherence 2014;8:925-31.
18. Aghdam KA, Aghaei H, Shokrollahi S, Joshaghani M, Nazari H, Hashemi M, et al. Comparison of the effect of cycloplegic versus NSAID eye drops on pain after photorefractive keratectomy. J Curr Ophthalmol 2015;27:87-91.
19. Toguri JT, Caldwell M, Kelly ME. Turning down the thermostat: modulating the endocannabinoid system in ocular inflammation and pain. Front Pharmacol 2016;7:304.
20. Mcmonnies CW. The potential role of neuropathic mechanisms in dry eye syndromes. J Optom 2017;10:5-13.
21. Kavoussi R. Pregabalin: from molecule to medicine. Eur Neuropsychopharmacol 2006;16:S128-33.
2. Belmonte C, Acosta MC, Merayo-Lloves J, Gallar J. What causes eye pain? Curr Ophthalmol Rep 2015;3:111-21.
3. Goulden CB. The control of ocular pain. Proc R Soc Med 1943; 36: 408-10.
4. Levitt AE, Galor A, Weiss JS, Felix ER, Martin ER, Patin DJ, et al. Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent postoperative pain disorders. Mol Pain 2015;11:21.
5. Quinto GG, Camacho W, Behrens A. Postrefractive surgery dry eye. Curr Opin Ophthalmol 2008;19:335-41.
6. Yoon SY, Bae SH, Shin YJ, Park SG, Hwang S-H, Hyon JY, et al. Low serum 25-hydroxyvitamin D levels are associated with dry eye syndrome. PLoS One. 2016;11:e0147847.
7. Roberts C, MacLeod J, Elkington A. Ocular pain: a casualty study. The spectrum and prevalence of pain in acute eye disease. Eye (Lond) 1997;11:342-4.
8. Espahbodi M, Noorossana R. Applied Statistics with Minitab Software for Analytical Chemistry.1st ed. Tehran: IUST, 2018.
9. Shah-Desai S, Tyers A, Manners R. Painful blind eye: efficacy of enucleation and evisceration in resolving ocular pain. Br J Ophthalmol 2000;84:437-8.
10. Matsuura M, Ando F, Sahashi K, Torii Y, Hirose H. The effect of stellate ganglion block on prolonged postoperative ocular pain. Nippon Ganka Gakkai Zasshi 2003;107:607-12.
11. Hsu JK, Johnston WT, Read RW, McDonnell PJ, Pangalinan R, Rao N, et al. Histopathology of corneal melting associated with diclofenac use after refractive surgery. J Cataract Refract Surg 2003;29:250-6.
12. Cho H, Wolf KJ, Wolf EJ. Management of ocular inflammation and pain following cataract surgery: focus on bromfenac ophthalmic solution. Clin Ophthalmol 2009;3:199-210.
13. Smith S, Lorenz D, Peace J, McLeod K, Crockett R, Vogel R. Difluprednate ophthalmic emulsion 0.05%(Durezol®) administered two times daily for managing ocular inflammation and pain following cataract surgery. Clin
Ophthalmol 2010;4:983-91.
14. Joshaghani M, Nazari H, Falavarjani KG, Shokrollahi S, Ghaempanah MJ, Aghdam KA, et al. Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study. Saudi J Ophthalmol 2013;27:83-5.
15. Roberts C, Elie E. Dry eye symptoms following cataract surgery. Insight 2007;32:14-21.
16. Galor A, Levitt RC, Felix E, Martin ER, Sarantopoulos C. Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond) 2015;29:301-12.
17. Rajpal RK, Ross B, Rajpal SD, Hoang K. Bromfenac ophthalmic solution for the treatment of postoperative ocular pain and inflammation: safety, efficacy, and patient adherence. Patient Prefer Adherence 2014;8:925-31.
18. Aghdam KA, Aghaei H, Shokrollahi S, Joshaghani M, Nazari H, Hashemi M, et al. Comparison of the effect of cycloplegic versus NSAID eye drops on pain after photorefractive keratectomy. J Curr Ophthalmol 2015;27:87-91.
19. Toguri JT, Caldwell M, Kelly ME. Turning down the thermostat: modulating the endocannabinoid system in ocular inflammation and pain. Front Pharmacol 2016;7:304.
20. Mcmonnies CW. The potential role of neuropathic mechanisms in dry eye syndromes. J Optom 2017;10:5-13.
21. Kavoussi R. Pregabalin: from molecule to medicine. Eur Neuropsychopharmacol 2006;16:S128-33.
| Files | ||
| Issue | Vol 59, No 6 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/acta.v59i6.6892 | |
| Keywords | ||
| Pregabalin Eye pain Cataract surgery | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Yousefshahi F, Majedi Ardakani H, Sanatkar M, Atef yekta R, Takzare A, Espahbodi E. Comparison of Pregabalin and Placebo Effects in Treating Eye Pain Following Cataract Surgery by Phacoemulsification Method. Acta Med Iran. 2021;59(6):346-350.
