Chordoma: Excellent Response to Radiotherapy in Combination With Hyperthermia
-
Mohammad Reza Barzegartahamtan
,
Ali Basil
,
Leila Khalafi
,
Zahra Falahatpour
,
Ali Mohamad
,
Seied Rabi Mahdavi
Abstract
Chordoma is a bone tumor that is resistant to radiotherapy, and few studies have been published on the concomitant use of radiotherapy in combination with hyperthermia in its treatment. We reported a chordoma patient treated with both radiotherapy and hyperthermia. The patient was a 74-year-old man with chordoma who underwent radiotherapy combined with hyperthermia due to his unwillingness to undergo surgery and responded very well clinically and imaging-wise without increasing in complications. Radiotherapy combined with hyperthermia improves the response to treatment (both clinically and in imaging) and does not increase the complications.
1. Bakker SH, Jacobs WCH, Pondaag W, Gelderblom H, Nout RA, Dijkstra PDS, et al. Chordoma: a systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival. Eur Spine J 2018;27:3043-58.
2. Tenny S, Varacallo M. Chordoma. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
3. Young VA, Curtis KM, Temple HT, Eismont FJ, DeLaney TF, Hornicek FJ. Characteristics and patterns of metastatic disease from chordoma. Sarcoma 2015;2015:517657.
4. Heery CR. 2016. Chordoma: the quest for better treatment options. Oncol Ther 2016;4:35-51.
5. Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, et al. Safety and local control of radiation therapy for chordoma of the spine and sacrum: a systematic review. Spine (Phila Pa 1976) 2016;41:S186-92.
6. Tran S, Puric E, Walser M, Poel R, Datta NR, Heuberger J, et al. Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas. Br J Radiol 2020;93:20180883.
7. Spratt JS, Martin AE, McKeown J. Sacral chordoma: a case study and review. J Surg Oncol 1981;18:101-3.
8. Valdagni R, Amichetti M; Dell'Orsola G. Local microwave hyperthermia in cancer therapy. Preliminary report. Tumori J 1982;68:247-51.
9. Sager O, FerratDincoglan SD, Beyzadeoglu M. Evaluation of Treatment Volume Determination for Irradiation of chordoma: an Original Article. Int J Res Stud Med Health Sci 2020;5:3-8.
10. Singh P. The Effect of Hyperthermia and Proton Radiation Therapy on Chordoma Cells [dissertation]. University of Maryland: Baltimore, 2019.
11. Mahdavi SR, Khalafi L, Nikoofar AR, Fadavi P, Arbabi Kalateh F, Aryafar T, et al. Thermal enhancement effect on chemo-radiation of glioblastoma multiform. Int J Radiat Res April 2020;18:255-62.
12. Keyvan B, Nikoofar A, Sanei M, Barzegar-Tahamtan M, Mahdavi SR, Khalafi L, et al. Comparison of the Effect of Combined Treatment with Radiotherapy and Hyperthermia versus Exclusively Radiotherapy to Reduce Pain in Patients with Bone Metastases. J Pharm Res Int 2020;32: 23-34.
13. Khalafi L, Mahdavi SRM, Arbabi F. THERMO-CHEMORADIATION INDUCED MR DIFFUSION CHANGES AFTER BRAIN GLIOMA TREATMENT. Glob J Adv Res 2019;6:157-62.
14. Datta NR, Bodis S. Hyperthermia with photon radiotherapy is thermoradiobiologically analogous to neutrons for tumors without enhanced normal tissue toxicity. Int J Hyperthermia 2019;36:1072-7.
15. Trifiletti DM, Brown PD. Proton and carbon ion therapy for skull base chordomas. Neuro Oncol 2020;22:1241-2.
16. Takagi M, Demizu Y, Nagano F, Terashima K, Fujii O, Jin D, et al. Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study. Radiat Oncol 2018;13:232.
2. Tenny S, Varacallo M. Chordoma. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
3. Young VA, Curtis KM, Temple HT, Eismont FJ, DeLaney TF, Hornicek FJ. Characteristics and patterns of metastatic disease from chordoma. Sarcoma 2015;2015:517657.
4. Heery CR. 2016. Chordoma: the quest for better treatment options. Oncol Ther 2016;4:35-51.
5. Pennicooke B, Laufer I, Sahgal A, Varga PP, Gokaslan ZL, Bilsky MH, et al. Safety and local control of radiation therapy for chordoma of the spine and sacrum: a systematic review. Spine (Phila Pa 1976) 2016;41:S186-92.
6. Tran S, Puric E, Walser M, Poel R, Datta NR, Heuberger J, et al. Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas. Br J Radiol 2020;93:20180883.
7. Spratt JS, Martin AE, McKeown J. Sacral chordoma: a case study and review. J Surg Oncol 1981;18:101-3.
8. Valdagni R, Amichetti M; Dell'Orsola G. Local microwave hyperthermia in cancer therapy. Preliminary report. Tumori J 1982;68:247-51.
9. Sager O, FerratDincoglan SD, Beyzadeoglu M. Evaluation of Treatment Volume Determination for Irradiation of chordoma: an Original Article. Int J Res Stud Med Health Sci 2020;5:3-8.
10. Singh P. The Effect of Hyperthermia and Proton Radiation Therapy on Chordoma Cells [dissertation]. University of Maryland: Baltimore, 2019.
11. Mahdavi SR, Khalafi L, Nikoofar AR, Fadavi P, Arbabi Kalateh F, Aryafar T, et al. Thermal enhancement effect on chemo-radiation of glioblastoma multiform. Int J Radiat Res April 2020;18:255-62.
12. Keyvan B, Nikoofar A, Sanei M, Barzegar-Tahamtan M, Mahdavi SR, Khalafi L, et al. Comparison of the Effect of Combined Treatment with Radiotherapy and Hyperthermia versus Exclusively Radiotherapy to Reduce Pain in Patients with Bone Metastases. J Pharm Res Int 2020;32: 23-34.
13. Khalafi L, Mahdavi SRM, Arbabi F. THERMO-CHEMORADIATION INDUCED MR DIFFUSION CHANGES AFTER BRAIN GLIOMA TREATMENT. Glob J Adv Res 2019;6:157-62.
14. Datta NR, Bodis S. Hyperthermia with photon radiotherapy is thermoradiobiologically analogous to neutrons for tumors without enhanced normal tissue toxicity. Int J Hyperthermia 2019;36:1072-7.
15. Trifiletti DM, Brown PD. Proton and carbon ion therapy for skull base chordomas. Neuro Oncol 2020;22:1241-2.
16. Takagi M, Demizu Y, Nagano F, Terashima K, Fujii O, Jin D, et al. Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study. Radiat Oncol 2018;13:232.
| Files | ||
| Issue | Vol 61 No 7 (2023) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/acta.v61i7.14499 | |
| Keywords | ||
| Chordoma Response Complication Radiotherapy Hyperthermia | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Barzegartahamtan MR, Basil A, Khalafi L, Falahatpour Z, Mohamad A, Mahdavi SR. Chordoma: Excellent Response to Radiotherapy in Combination With Hyperthermia. Acta Med Iran. 2023;61(7):432-434.
