2023 CiteScore: 0.7
pISSN: 0044-6025
eISSN: 1735-9694
Editor-in-Chief:
Ahmadreza Dehpour, PharmD, PhD
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE).
Vol 5, No 1-4 (1962)
Articles
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A new and efficient organization of the early preventron of rabies in man can be proposed thanks to the serum prepared by the Razi Insti~ute in the dried form. This serum, highly concentrated, has therefore an outstanding potency, but a complete innocuity; its dry state allows a perfect c~nservation without special precautions. All medical centers, e.ven the m?st re~ote m the parts Of,the country where rabies remains enzootic, WIll be provided WIth a reserve of this serum, so that eventlhe peasants of the most distant vmages can receive the saving injection .in time, i.e. during the seventy two hours after the inoculation of the virus by the biting animal. Under the protection of the serum the sending of the wounded tow~rds Teheran is 'not, as in the past, a dramatic emergency and would be avoided in many cases. ThLis paper gives then to the physicians the necessary hints, not only for the use of the serum and the wound treatment, but also for the observation of the wounded and of the biting animal.
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An interference is observed between whooping-cough antigens and Salk polioc vaccine even if the two components are mixed immediately before use. The phenomenon is more evident when flUlid antigens are injected. Pertussis soluble antigen, which gives a good serological response in rabbits, when used alone or combined with DT, is inactivated in the presence of Salk polio vacc:ne
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In Iran, the prevention of poliomyelitis is practically limited to vaccinatton This paper, however, gives a detailed account of the preventive measures attempting to check the spread of the infection and of those aiming at the reduction of the frequency of the paralytic manifestation
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;rhe di~cove!y of antibiotics having an highly effective and specific action on th~ rickettsial diseases has greatly' deprived of importance the formerly outstanding prevention of these diseases. However, the prevention of Typhus: fever, the single rickettsiosis to be purely human and the <;>nly. one to: be epidemic, remains an important problem. The methods of. prevention.m the mveterate foci 'can be determined in the light of the last attainments, WhICh are: non-transmission of the infection by the bite of the louse, ~pread by the dusty faeces of the ectoparasite, long-lived conservation of the VIruS ~ that dust, possibility of lasting latency in man and of resurgences from the earner
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Conclusions based on 72 proven cases of B~cellosis obsed"Ve.d at ~he Infectious Diseases Department of Pahlavi HOSPItal, Tehran University, School of Medicine from 1958-1962 are as follow:-
1. Age Incidence: Highest between the ages of 20 to 40.
2. Seasonal Incidence: Highest during the summer months.
3. Occupational Relationship and Incidence: In 90% of th~ cases, there was no contact between the patients and the infected animals or their products.
4. Sex Incidence: The majority of our cases, (68.0%) were men.
5. Despite the prevalence of Hr. abortus among the c~ttle of tAlh~ Tehran area human Brucellosis due to Hr. abortus IS rare. the reported cases were due to Hr. mclitensi~.
6. The difference between the symptomatology in our cahsesdiaffnd those of foreigners are described. The~ may be ~ue ~o. t €I . ~renee in the casual agent and to the difference m living conditions in Iran.
7. The Incidence of Brucellosis in children is extremely low. This may be due to their natural resistance and to their more limited living conditions.
8. The .disease is almost absent in occupationally exposed people, despite the number of infected cattle in the Tehran area. This may be due to the low pathogenic potency of Hr. abortus in Iran..
9. Mode of Transmisainn ; Not discounting the possibility of transmission through the alimentary tract, we suggest that Brucella excreted by the goats kept in the city or those which belong to the tribes who pass some times during winter and summer
movement in the cities, may mix with the dust and air and so ain entrance to the respiratory system.
10. Therapy: Best results in chronic cases were obtained througn
an association of Tetracycline derivative with Sulfonamides and Streptomycine. Chloramphenicol has yielded good results, although in some cases the illness may recur.
